![]() low risk) and GAD65A did not (P = 0.81 and 0.86, respectively). The 4-year diabetes risk was higher in single BAA+ relatives with ZnT8A than ZnT8A– relatives (31 vs. RESULTS: ZnT8A were associated with the other BAA (548 of 2,256 BAA+ vs. ZnT8A were also tested in 911 randomly chosen antibody-negative relatives. RESEARCH DESIGN AND METHODS: For this analysis, 2,256 relatives positive for at least one BAA, of whom 142 developed diabetes, were tested for ZnT8A, ICA, and HLA genotype followed by biannual oral glucose tolerance tests. OBJECTIVE: We assessed diabetes risk associated with zinc transporter-8 antibodies (ZnT8A), islet cell antibodies (ICA), and HLA type and age in relatives of people with type 1 diabetes with the standard biochemical autoantibodies (BAA) to insulin (IAA), GAD65 (GAD65A), and/or insulinoma-associated protein 2 antigen (IA-2A). ZnT8A should be included in type 1 diabetes prediction and prevention studies. ZnT8A predicted diabetes independently of ICA, the standard BAA, age, and HLA type. CONCLUSIONS: In relatives with one standard BAA, ZnT8A identified a subset at higher diabetes risk. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |